No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
21 – 60
Sex
Any
Trial phase
Phase 4
Study type
Interventional
Purpose
Treatment
Participants needed
60 (estimated)
Sponsor
University of Virginia · Other
Who this trial is looking for
This trial is looking for adults with type 2 diabetes to explore how exercise and liraglutide treatment together or separately can improve heart and muscle health. Participants will need to engage in either exercise, receive liraglutide, or both for 16 weeks.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 21 and 60 years old.
I have been diagnosed with type 2 diabetes.
My A1C level is 8.5% or lower.
I have not used GLP-1RA or DPP4I medications before.
I have been on a stable dose of oral diabetes medications for over 4 months.
I have been on a stable dose of other medications for over 4 months.
You may not be able to join if
I am currently taking insulin.
I have smoked in the past 6 months.
My blood pressure is higher than 160/90.
My BMI is over 35.
I have a family history of medullary thyroid cancer.
I have a history of heart or severe lung disease.
I have had a stroke or heart attack.
I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: ex…
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and muscle capillary blood volume, improves vascular function in the larger conduit vessels, and enhances insulin's metabolic action in humans with Type 2 diabetes. Subjects will be randomized to one of the three groups: exercise training, liraglutide treatment, and exercise + liraglutide. They will be studied at the baseline and then after 16 weeks of intervention.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 21-60
* A1C ≤ 8.5%
* Never on GLP-1RA (eg: exenatide, liraglutide) or DPP4I ( eg: Sitaglipton)
* On stable dose of oral hypoglycemic agents \>4 months
* On stable dose of other medications for \>4 months
Exclusion Criteria:
* Taking Insulin
* Smoking presently or in the …
Inclusion Criteria:
* Age 21-60
* A1C ≤ 8.5%
* Never on GLP-1RA (eg: exenatide, liraglutide) or DPP4I ( eg: Sitaglipton)
* On stable dose of oral hypoglycemic agents \>4 months
* On stable dose of other medications for \>4 months
Exclusion Criteria:
* Taking Insulin
* Smoking presently or in the past 6 months
* BP \>160/90
* BMI \>35
* Family history of medullary thyroid cancer or multiple endocrine neoplasia syndrome
* History of congestive heart failure, ischemic heart disease, severe pulmonary disease, liver or kidney disease.
* Any vascular disease such as myocardial infarction, stroke, peripheral vascular disease
* Presence of an intracardiac or intrapulmonary shunt (we will screen for this by auscultation during the physical exam by PI).
* Pregnant or breastfeeding.
* Known hypersensitivity to perflutren (contained in Definity)
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