Pegloticase for Youth-Onset Type 2 Diabetes
Uric Acid Lowering Trial in Youth Onset T2D
Recruiting
Phase 2
Interventional Study
Diabetic Kidney Disease
Hyperuricemia
Diabetes
Diabetes Mellitus, Type 2
Type2 Diabetes
Type 2 Diabetes Mellitus
Diabetic Nephropathies
Diabetes Complications
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 25
- Sex
- Male
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 10 (estimated)
- Sponsor
- University of Colorado, Denver · Other
Who this trial is looking for
This trial is looking for young men aged 18-25 who were diagnosed with type 2 diabetes before age 21. Participants will receive treatment with pegloticase for 7 days to see how it affects their health.
Are You a Good Fit for This Trial?
You may be able to join if
- I am a man
- I am between 18-25 years old
- I have been diagnosed with type 2 diabetes
- My serum uric acid is 5 mg/dl or higher
You may not be able to join if
- I have glucose-6-phosphate deficiency
- I have allergies to seafood or iodine
- I cannot have an MRI due to severe claustrophobia or other reasons
- My HbA1C is 12% or higher
- I was diagnosed with diabetic ketoacidosis or hyperosmolar hyperglycemia in the last month
- I have congestive heart failure
- I have a history of severe allergies or anaphylactic reactions
- I am taking any uric acid lowering medications
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Adolescents and young adults with youth-onset type 2 diabetes (T2D) are disproportionally impacted by hyperuricemia compared to non-diabetic peers and youth with type 1 diabetes (T1D). In fact, 50% of males with youth-onset T2D have serum uric acid (SUA) greater than 6.8 mg/dl. The investigators also recently demonstrated that higher SUA conferred greater odds of developing hypertension and diabet…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Men
* Ages 18-25
* Youth-onset T2D (diagnosis \<21 years)
* serum uric acid ≥ 5 mg/dl
Exclusion Criteria:
* Glucose-6-phosphate (G6P) deficiency
* Allergies to seafood or iodine
* MRI contraindications (severe claustrophobia, non-MRI compatible implantable devices, weight ≥ …
Contacts