Evaluation of Local Co-administration of Autologous ADIpose Derived Stromal Vascular Fraction With Microfat for Refractory Perianal CROHN's Fistulas.

Inclusion Criteria: * Signed informed consent * Patients with Crohn's Disease (CD) diagnosed at least 6 months earlier in accordance with accepted clinical, endoscopic, histological and/or radiologic criteria * Presence of refractory complex perianal fistulas assessed by clinical assessment during examination under anaesthesia (preparation treatment) and MRI. * Non-active or mildly active luminal CD defined by a CDAI ≤ 220 * Patients of either sex aged 18 years or older * Good general state of health according to clinical history and a physical examination * For women of a childbearing age, they must have negative serum or urine pregnancy test (sensitive to 25 IU human chorionic gonadotropin \[hCG\]). Both men and women should use appropriate birth control methods defined by the investigator. Exclusion Criteria: * Presence of dominant luminal active Crohn's disease requiring immediate therapy * CDAI \> 220 * Patient naïve to specific treatment for perianal fistulising Crohn's disease * Presence of an abscess or collections \> 2 cm, unless resolved in the preparation procedure * Rectal and/or anal stenosis if this means a limitation for any surgical procedure * Patient with ongoing steroid treatment or treated with steroids in the last 4 weeks * Malignant tumour or patients with a prior history of any malignant tumour, including any type of fistula carcinoma * Current or recent history of abnormal, severe, progressive, uncontrolled infectious, hepatic, haematological, gastrointestinal (except CD), endocrine, pulmonary, cardiac, neurological, psychiatric, or cerebral disease * Congenital or acquired immunodeficiencies * Contraindication to local anaesthetics or gadolinium (MRI contrast) * Contraindication to MRI scan, (e.g., due to the presence of pacemakers, hip replacements or severe claustrophobia) * Pregnant or breastfeeding women * Contraindication to the anaesthetic or surgical procedure * BMI \< 18 to insure adequate abdominal or other subcutaneous adipose tissue accessible by lipoharvest * Any active viral infection follows: HIV, HTLV I et II, VHB, VHC and Syphillis