Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiotherapy

Inclusion Criteria: 1. Age ≥ 18 years old 2. ECOG performance status ≤ 2 3. Female and Male 4. Newly diagnosed, histologically confirmed primary squamous cell carcinoma of the oropharynx 5. Candidate for curative intent radiotherapy and systemic treatment 6. No prior or current anticancer treatment for the HNSCC (e.g. neo-adjuvant chemotherapy, surgery) 7. Diagnosis biopsy results 8. HPV/p 16 testing results 9. Serum test (for subjects of childbearing potential) negative within 7 days prior to the 1st CRT administration. 10. Women of childbearing potential must agree to use of one highly effective method of contraception prior study entry, during the course of the study and at least 6 months after the last administration of cisplatin. 11. Men with childbearing potential partner must agree to use condom during the course of this study and for at least 6 months after the last administration of the cisplatin. 12. Adequate bone marrow function as defined below: * Absolute neutrophil count (ANC) ≥1500/µL or 1.5x109/L * Hemoglobin ≥ 9 g/dL * Platelets ≥100000/µL or 100x109/L 13. Adequate liver function as defined below: * Serum total bilirubin ≤ 1.5 x ULN. In case of known Gilbert's syndrome \< 3 x UNL is allowed * AST (SGOT)/ALT (SGPT) ≤ 2.5 x ULN * Alkaline phosphatase ≤ 2.5 x ULN 14. Adequate renal function as defined below: * Creatinine ≤ 1.5 x UNL and creatinine clearance \> 60 mL/min 15. Peripheral neuropathy ≤ grade 1 16. Hear impaired ≤ grade 1 17. Completion of all necessary screening procedures within 15 days prior to randomisation. 18. Signed Informed Consent form (ICF) obtained prior to any study related procedure. 19. Ability to understand and complete the questionnaires (language proficiency, cognitive functioning) as judged by principal investigator upon screening Exclusion Criteria: 1. Severe malnutrition 2. Dysphagia requiring a liquid or puree texture modified diet (grade ≥ 2 (CTCAE\_v.5) 3. Distant metastasis 4. Serious coagulation disorders (INR\>1.5, PTT\>50s, platelets \<50000/mm3) 5. Subject with a significant medical, neuro-psychiatric, or surgical condition, currently uncontrolled by treatment, which, in the principal investigator's opinion, may interfere with completion of the study. 6. Other malignancies in the 3 years prior to study entry except of surgically cured carcinoma in situ of the cervix, in situ breast cancer, incidental finding of stage T1a or T1b prostate cancer, and basal/squamous cell carcinoma of the skin; 7. Pregnant and/or lactating women. 8. Known hypersensitivity to the study drug (cisplatin) or excipients.