Standard Injections Versus Reduced Injections for Intravesical onabotulinumtoxinA Treatment of Overactive Bladder

Inclusion Criteria: * Males or Females ≥ 18 years of age * Predominant complaint of urinary urgency, urinary frequency or urge incontinence * Failed at least one medication (inadequate or poorly tolerated response) or behavior modification technique (timed voiding, pelvic floor physical therapy, etc.), or decline such interventions * Willingness to perform self-catheterization in the event of symptomatic urinary retention * Ability to follow study instructions and likely to complete all required follow-up Exclusion Criteria: * Concurrent use of oral medications for treatment of OAB (anticholinergics or beta 3 agonists). * Post void residual volume \> 200 ml * Symptomatic prolapse \> POP-Q (Pelvic Organ Prolapse Quantification) stage 2 or greater that is untreated * Evidence of active UTI (bladder infection) * Any previous use of intradetrusor botulinum toxin (onabotulinumtoxinA or abobotulinumtoxinA) within the preceding 6 months * Use of \>/= 400 units bontulinum toxin in the preceding 3months in other areas of the body * Procedure performed in the main operating room (not outpatient setting) * Concurrent diagnosis of interstitial cystitis/painful bladder syndrome * Females who are pregnant or planning a pregnancy during the study or who think that they may be pregnant at the start of the study, or females of childbearing potential who are unable or unwilling to use a reliable form of contraception during the study. * Any medical condition that may put the subject at increased risk with exposure to botulinum-A toxin, including diagnosed myasthenia gravis, Eaton-Lambert syndrome, amyotrophic lateral sclerosis/motor neuron disease, neuropathy, renal stones, or any other disorder that might interfere with neuromuscular function * Known allergy or sensitivity to any of the components of onabotulinumtoxinA * Concurrent participation in another investigational drug or device study that could impact the results * Any condition or situation that, in the investigator's opinion, may put the subject at significant risk, confound the study results, or interfere significantly with the subject's participation in the study