Imaging Synapses With [11C] UCB-J in the Human Brain
Recruiting
Phase 1
Interventional Study
Schizophrenia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 60 (estimated)
- Sponsor
- Davidzon, Guido, M.D. · Other
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About This Trial
The purpose of this study is to utilize the radioactive positron emission tomography (PET) tracer \[11C\]UCB-J to test the neural synaptic pruning hypothesis of schizophrenia. This imaging method allows for the quantification of synaptic density in the living human brain and has the unprecedented ability to directly examine the synaptic pathology underlying neuropsychiatric disease. The neural syn…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* 18 - 65 years in age
* For SZ participants:
* On a stable medication regimen for at least two weeks prior to testing
* A clinical diagnosis of schizophrenia, schizophreniform, or schizoaffective disorder
* Able to complete a PET-MR scan without the use of sedation
Excl…
Contacts