Binimetinib Plus Encorafenib Real Life Investigation of Next Generation Melanoma Treatment

Inclusion Criteria: * Written informed consent of the patient with regard to the pseudonymized documentation as well as the transfer and processing of his/her data within the study and the ADOREG \[Cancer Registry of German Working Group of Dermato-Oncology\] registry (data transfer to ADOREG registry only for patients from German sites); * Legally capable male or female patient ≥ 18 years of age (no upper limit); * Decision was taken to treat the patient with encorafenib plus binimetinib in accordance with the current SmPC \[Summary of Product Characteristics\] and by prescription; this decision was taken prior to and independent from the inclusion into the study; * Treatment with encorafenib plus binimetinib has been started ≤ 6 months prior to providing written informed consent for this study or is planned to be started in the near future; * Unresectable advanced or metastatic malignant melanoma with BRAF \[Rapidly Accelerated Fibrosarcoma isoform B\] V600 mutation; * Treatment-naive or after one prior line of checkpoint inhibitor treatment (anti-CTLA4 \[Cytotoxic T-Lymphocyte Antigen-4\] and/or anti-PD(L)1 \[Programmed cell Death protein 1\]) in the unresectable advanced or metastatic setting. Exclusion Criteria: * Previous treatment with a BRAF- and/or MEK \[Mitogen-Activated Protein/Extracellular-signal Regulated Kinase\]- inhibitor except for: \-- prior adjuvant treatment with BRAF+MEK-inhibitor combination therapy that ended \> 6 months prior start of Encorafenib/Binimetinib treatment; * More than one prior line of checkpoint inhibitor treatment in the unresectable advanced or metastatic setting; * Any previous chemotherapeutic treatment of the melanoma disease; * Presence of any contraindication with regard to the encorafenib-binimetinib-treatment as specified in the corresponding SmPCs; * Current or upcoming participation in an interventional clinical trial; * Current or upcoming systemic treatment of any other tumor than melanoma; * Prisoners or persons who are compulsorily detained (involuntarily incarcerated).