Genetic Causes of Discrepant Clinic in Monogenic Twins
Recruiting
Observational Study
Rare Diseases
Genetic Predisposition to Disease
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Sex
- Any
- Study type
- Observational
- Participants needed
- 50 (estimated)
- Sponsor
- University Hospital Tuebingen · Other
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About This Trial
In the DISCO-TWIN study (prospective, open-label molecular-genetic study), twin pairs with one healthy and one affected twin with molecularly undiagnosed diseases will be analysed by means of omics technologies and/ or re-analysed using existing datasets. Phenotype and omics data will be shared within the University Hospital Tübingen and with external collaborators to improve the diagnostic rate o…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Twin pair monozygotic clinically (phenotypic) discordant twins
* Unclear diagnosis
* Suspected (mono-)genetic cause of the disease in one twin
Exclusion Criteria:
* Missing informed consent of both twin/ legal representative
* No distinct phenotype
Contacts