Modified Radical Mastectomy vs Mckissock Surgery for Breast Cancer
DFS and QOL After Modified Radical Mastectomy vs. Expanded Mckissock Surgery for EIC of the Breast
Recruiting
N/AInterventional Study
Breast Neoplasms
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
45 – 75
Sex
Female
Study type
Interventional
Purpose
Treatment
Participants needed
200 (estimated)
Sponsor
Shengjing Hospital · Other
Who this trial is looking for
This trial is looking for women who have a specific type of breast cancer called extensive intraductal carcinoma. Participants will either receive modified radical mastectomy or a newer surgical technique called expanded Mckissock surgery and will be followed for their recovery and quality of life.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with extensive intraductal carcinoma.
My breast lesion does not involve the nipple.
I am postmenopausal.
I have a bra cup size of B or higher.
I can provide written informed consent.
You may not be able to join if
I have had positive test results for extensive intraductal carcinoma at the nipple.
I have experienced nipple bleeding before surgery.
I have breast cancer in both breasts.
I have inflammatory breast cancer.
I have cancer that has spread to other parts of my body.
I have another type of cancer or have received chest radiotherapy.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Extensive intraductal carcinoma of the breast refers to a type of breast cancer in which ≥ 25% of ductal carcinoma in situ is present in invasive tumors and there is a scattered distribution of ductal carcinoma in situ (DCIS) in or around the invasive carcinoma. Compared with DCIS negative for extensive intraductal component, DCIS positive for extensive intraductal component is not sensitive to ra…
Extensive intraductal carcinoma of the breast refers to a type of breast cancer in which ≥ 25% of ductal carcinoma in situ is present in invasive tumors and there is a scattered distribution of ductal carcinoma in situ (DCIS) in or around the invasive carcinoma. Compared with DCIS negative for extensive intraductal component, DCIS positive for extensive intraductal component is not sensitive to radiotherapy. Mckissock surgery was applied in breast-conserving surgery for breast cancer in 2016. Jianyi Li and the team members (Shengjing Hospital of China Medical University, Shenyang, China) applied this technique in breast-conserving surgery with preservation of the nipple-areola complex. This surgical technique is suitable for low-grade malignant tumors and has better prognosis than radical mastectomy. The purpose of this study is to investigate postoperative disease-free survival and quality of life after modified radical mastectomy versus expanded Mckissock surgery for extensive intraductal carcinoma of the breast. Results from this study will indicate the efficacy of expanded Mckissock surgery in the treatment of extensive intraducatal carcinoma of the breast.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients with extensive intraductal carcinoma confirmed by hollow needle biopsy;
* the lesion not involving the nipple as confirmed by enhanced MR imaging of the breast;
* Bra cup size: B or higher;
* postmenopausal patients;
* provision of written informed consent.
Exclusion…
Inclusion Criteria:
* Patients with extensive intraductal carcinoma confirmed by hollow needle biopsy;
* the lesion not involving the nipple as confirmed by enhanced MR imaging of the breast;
* Bra cup size: B or higher;
* postmenopausal patients;
* provision of written informed consent.
Exclusion Criteria:
* The cutting edge of nipple-areola complex tested positive for extensive intraductal carcinoma twice;
* preoperative nipple hemorrhage;
* bilateral breast cancer;
* inflammatory breast cancer;
* distant metastasis;
* other cancers or those who receive chest radiotherapy.
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