Sacubitril/Valsartan for Improving Metabolic Health
NAUTICAL: Effect of Natriuretic Peptide Augmentation on Cardiometabolic Health in Black Individuals
Recruiting
Phase 2
Interventional Study
Diabetes Mellitus
Cardiovascular Diseases
Insulin Sensitivity/Resistance
Metabolic Disease
Natriuretic Peptides
Metabolism
Energy Expenditure
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 200 (estimated)
- Sponsor
- University of Alabama at Birmingham · Other
Who this trial is looking for
This trial is looking for Black adults aged 18 and older to test if a medication can improve their metabolic health by boosting specific hormones. Participants will help understand the role these hormones play in diabetes risk.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years of age or older
- I identify as African-American or Black
- My blood pressure is between 120-160/80-100 mmHg
You may not be able to join if
- I am pregnant, breastfeeding, or can become pregnant and not using birth control
- I have had a heart attack or stroke
- My blood pressure is above 160/100 mmHg
- My BMI is over 45
- I have a history of diabetes
- I have had angioedema
- I currently smoke or have smoked in the last year
- I have significant psychiatric illness
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Black individuals are more likely to have decreased insulin sensitivity which results in a high risk for the development of cardiometabolic disease. The reasons for this are incompletely understood. Natriuretic peptides (NPs) are hormones produced by the heart that play a role in regulating the metabolic health of an individual. Low circulating level of NPs is an important contributor to increased…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Adults: Age more than or equal to 18 years of age
* Self-identified race/ethnicity as African-American or Black
* Blood pressure: 120-160/80-100 mmHg
Exclusion Criteria:
* Women who are pregnant or breastfeeding or who can become pregnant and not practicing an acceptable met…
Contacts