Correlation of Radiological Lesions With Vestibular Function in Patients With Bilateral Vestibulopathy
Recruiting
Observational Study
Hearing Loss, Sensorineural
Bilateral Vestibular Deficiency
DFNA9
Radiology
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 – 90
- Sex
- Any
- Study type
- Observational
- Participants needed
- 40 (estimated)
- Sponsor
- Jessa Hospital · Other
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About This Trial
In 2014 radiologic lesions were detected at one or more semicircular canals using CT and MR imaging of temporal bone in subjects carrying the p.P51S mutation in COCH. These lesions are believed to present at more advanced stages of the hearing and vestibular deterioration. Since then, other authors have described similar lesions in advanced non-genetic hearing and vestibular impairment as well.
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Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* must meet the Barany criteria for bilateral vestibulopathy: bilaterally pathological horizontal angu- lar VOR gain \<0.6, measured by the video-HIT5 or scleral-coil technique and/or
* reduced caloric response6 (sum of bither- mal max. peak SPV on each side \<6◦/sec7) and/or
* …
Contacts