Checkpoint Inhibitors for Cancer and Autoimmunity

Autoimmunity After Checkpoint Blockade

Recruiting Observational Study
Autoimmunity Cancer Immunotoxicity Oncology
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
600 (estimated)
Sponsor
Abramson Cancer Center at Penn Medicine · Other
Who this trial is looking for

This trial is looking for people with cancer who are receiving treatment with checkpoint inhibitors. Participants will help researchers understand why some patients develop immune-related side effects from this treatment.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with cancer
  • I have a prescription for a checkpoint inhibitor

You may not be able to join if

  • I am not willing or able to give consent
  • I am under the age of 18
  • I have a history of transplant

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.

Check Your Eligibility
About This Trial

The purpose of this study is to better understand how the treatment of cancer with immune checkpoint inhibitors (ICI) leads to the development of autoimmunity. Specifically, we wish to understand the genetics and immune system features that cause a subset of cancer patients treated with checkpoint inhibitor therapy to develop an immune-related adverse event (irAE).

Trial Locations
Loading…

Loading trial locations…

Eligibility Criteria
Inclusion Criteria: * A diagnosis of cancer and prescription for a checkpoint inhibitor Exclusion Criteria: * Any subjects not willing or able to give consent * Children under the age of 18 * A history of transplant
Contacts

Kyra J Sacksith

215-898-9339

kyra.sacksith@pennmedicine.upenn.edu

CONTACT