COLO-COHORT (Colorectal Cancer Cohort) Study

Inclusion Criteria: Group A * Aged ≥30 years\* and able to give informed consent * Patients attending colonoscopy * Through Bowel Cancer Screening Programme (FIT positive, Bowelscope conversion, surveillance) * Through standard NHS care (most commonly due to iron deficiency anaemia, altered bowel habit, weight loss, rectal bleeding, planned polypectomy\*\*, those referred on basis of family history, abnormal cross-sectional imaging, polyp surveillance or post CRC surveillance) * The age of 30 was chosen to ensure that this is a population likely to be enriched for colorectal neoplasia with neoplasia below this age uncommon \*\*In those attending for planned polypectomy, the results from the initial colonoscopy and the endoscopy where the polypectomy is undertaken will be summated for purposes of calculating the neoplasia profile (COLO-SPEED) Group B * Any patient attending for colonoscopy and able to give informed consent * ≥ 18 years old * Patient from the North of England Exclusion Criteria: Group A * Unable to give informed consent * Known polyposis syndrome * Previous total colectomy * Known colonic stricture which would limit complete colonoscopy * Attending for planned therapeutic procedure other than polypectomy, such as insertion of colonic stent * Attending for assessment of known inflammatory bowel disease (IBD) activity or for IBD surveillance * Patients currently recruited into an interventional CTIMP for CRC prevention\* COLO-SPEED (Group B) \*\* * Unable to give informed consent * Not in a centre supported by COLO-SPEED infrastructure (North of England)