Review the details below, then apply to join this clinical trial.
At a Glance
Age
50 – 90
Sex
Any
Study type
Interventional
Purpose
Prevention
Participants needed
1,988 (estimated)
Sponsor
Peking University First Hospital · Other
Who this trial is looking for
This trial is looking for patients aged 50 to 90 who are scheduled for surgery for lung cancer. Participation involves management of blood pressure during surgery and the use of dexamethasone to see how these affect recovery.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 50 and 90 years old.
I have been diagnosed with resectable non-small cell lung cancer.
I am scheduled for radical surgery lasting more than 2 hours.
I agree to participate in this study and sign the consent form.
You may not be able to join if
I have non-resectable lung cancer.
I have recurrent or metastatic lung cancer.
I have a history of cancer in other organs.
I have frequently taken glucocorticoids or immunosuppressants.
I have uncontrolled high blood pressure.
I have had heart problems like atrial fibrillation in the last 3 months.
I have severe liver dysfunction or kidney failure.
My doctor thinks I should not participate.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investiga…
Surgery is the front-line therapy for non-small cell lung cancer (NSCLC) but postoperative complications remains high and patients' long-term outcome is still challenging. In addition to surgery, anesthetic management particularly intraoperative blood pressure management and use of dexamethasone may affect patients' early and long-term outcomes after surgery for NSCLC. This study aims to investigate the impact of intraoperative blood pressure management and dexamethasone administration on early and long-term outcomes in patients undergoing surgery for lung cancer.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Aged \>50 years but \<90 years.
* Diagnosed as resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery with an expected duration of \>2 hours.
* Agree to participate in this study and sign the informed consent.
Exclusion Criteria:
* Cl…
Inclusion Criteria:
* Aged \>50 years but \<90 years.
* Diagnosed as resectable primary non-small cell lung cancer (stage IA-IIIA) and scheduled for radical surgery with an expected duration of \>2 hours.
* Agree to participate in this study and sign the informed consent.
Exclusion Criteria:
* Clinical examinations suggest non-resectable lung cancer or patients scheduled for a biopsy surgery.
* Recurrent or metastatic lung cancer.
* History of cancer or complicated with cancer in other organs.
* Long-term exposure to glucocorticoids or other immunosuppressant(s) due to autoimmune disease or organ transplantation.
* Uncontrolled hypertension (systolic blood pressure \>180 mmHg or diastolic blood pressure \>110 mmHg); or requirement of vasopressors to maintain blood pressure.
* Persistent atrial fibrillation, or acute cardiovascular events (acute coronary syndrome, stroke, or congestive heart failure) within 3 months.
* Severe hepatic dysfunction (Child-Pugh C) or renal failure (requirement of renal replacement therapy).
* Any other circumstances considered unsuitable for study participation by attending physicians or investigators.
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