No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
13 – 39
Sex
Any
Study type
Observational
Participants needed
150 (estimated)
Sponsor
Hari Narayan · Other
Who this trial is looking for
This trial is looking for young people who had cancer treatment with certain drugs called anthracyclines. Participants will undergo heart imaging to help researchers understand the effects of these treatments on heart health.
Are You a Good Fit for This Trial?
You may be able to join if
I am between 13 and 39 years old
I was diagnosed with cancer before age 22
I have received anthracycline therapy for cancer at least two years ago
I can speak English or Spanish
You may not be able to join if
I cannot have a cardiac MRI due to certain medical devices in my body
I have a medical or social condition that affects my ability to complete the study testing
I have a significant history of congenital heart disease
I am pregnant
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart f…
Anthracycline chemotherapies (e.g. doxorubicin, daunorubicin) are commonly given to treat pediatric cancer, and carry a risk of cardiotoxicity. Over the long term, children who receive these therapies have an increased risk of heart failure and early cardiovascular death. However, current strategies for identifying patients who are at risk prior to the development of significant changes in heart function are limited. This study will focus on imaging markers of cardiac injury and dysfunction with the goal of developing improved diagnostic tests and treatment strategies.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* English and Spanish speaking male and female subjects, ages 13-39 years old
* Diagnosis of cancer at age \<22 years
* Previously treated with anthracyline therapy for cancer, with diagnosis at least two years prior.
Exclusion Criteria:
* Patients who have a contraindication …
Inclusion Criteria:
* English and Spanish speaking male and female subjects, ages 13-39 years old
* Diagnosis of cancer at age \<22 years
* Previously treated with anthracyline therapy for cancer, with diagnosis at least two years prior.
Exclusion Criteria:
* Patients who have a contraindication to cardiac MRI, including the presence of non-MRI compatible metallic implants.
* Medical, psychiatric, and/or social disorder that would prevent successful completion of planned study testing or would preclude the subject from undergoing the cardiac MRI without anesthesia.
* Patients with a history of congenital heart disease (more significant than a history of patent foramen ovale or patent ductus arteriosus).
* Pregnancy (at the time of enrollment).
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