[18F]F-TMP PET/CT Imaging for Bacterial Infections
[18F]Fluoropropyl-Trimethoprim ([18F]F-TMP) PET/CT Imaging to Evaluate Biodistribution and Kinetics in Human Subjects
Recruiting
Phase 1Interventional Study
Bacterial Infections
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Other
Participants needed
20 (estimated)
Sponsor
University of Pennsylvania · Other
Who this trial is looking for
This trial is looking for adults with known or suspected bacterial infections. Participants will receive a special imaging injection to help doctors see how the infection is behaving in the body using a type of scan called PET/CT.
Are You a Good Fit for This Trial?
You may be able to join if
I am at least 18 years old.
I have a known or suspected bacterial infection.
I can understand the study and provide written consent.
You may not be able to join if
I have taken trimethoprim antibiotics in the last 48 hours.
I cannot tolerate imaging procedures.
I have severe medical or psychological issues that might affect my safety.
I am pregnant or breastfeeding.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to study a radioactive tracer, a type of imaging drug that is injected into the body to see how it is taken up in sites of active infection using an imaging procedure called Positron Emission Tomography/Computed Tomography (PET/CT).
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* At least 18 years of age
* Known or suspected bacterial infection, per clinical documentation of suspected infection (e.g. lab results, pathology results, physician progress notes, clinical symptoms of infection)
* Able to understand the investigational nature of this study an…
Inclusion Criteria:
* At least 18 years of age
* Known or suspected bacterial infection, per clinical documentation of suspected infection (e.g. lab results, pathology results, physician progress notes, clinical symptoms of infection)
* Able to understand the investigational nature of this study and provide written informed consent in accordance with institutional and federal guidelines prior to study-specific procedures
Exclusion Criteria:
* Antibiotic therapy with trimethoprim within 48h of the baseline PET/CT scan
* Inability to tolerate imaging procedures, in the opinion of an investigator or treating physician
* Unstable or other severe medical or psychological comorbidities that would compromise the subject's safety or successful participation in the study, in the opinion of an investigator or treating physician
* Pregnant or breast feeding patients; a urine pregnancy test will be performed in women of child-bearing potential prior to \[18F\]F-TMP injection, to confirm non-pregnant status
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