Early De-escalation of Empirical Antibiotics Treatment for Neutropenic Fever
Recruiting
N/A
Interventional Study
Safety Issues
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 65
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 200 (estimated)
- Sponsor
- Shanghai Jiao Tong University School of Medicine · Other
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About This Trial
This is a randomized study to evaluate the safety and feasibility of early de-escalation of empirical antibiotics treatment in neutropenic fever patients undergoing hematopoietic stem cell transplantation (HSCT). In case of afebrile for 72 hours with empirical antibiotics treatment, patients will be randomized into 2 groups. In the early de-escalation group, antibiotics treatment will be stopped a…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥18，patients undergo hematopoietic stem cells
* Patients with neutropenic fever: T≥38.5°C once or T≥38°C twice a day with ANC \<0.5x109/L or predicted to be \<0.5x109/L in 24 \~48 hours；
* Patients achieved afebrile （T\<37.5°C）for at least 72 hours；
* Inform consent given
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Contacts