Tasurgratinib for Mild to Moderate Liver Problems

Study to Evaluate the Pharmacokinetics (PK) of E7090 (Herein Referred to as Tasurgratinib) and Its Metabolite in Participants With Mild and Moderate Hepatic Impairment Compared to Healthy Participants

Recruiting Phase 1 Interventional Study
Hepatic Impairment
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Healthy Volunteers Welcome You do not need to have the condition being studied to take part.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
20 – 79
Sex
Any
Trial phase
Phase 1
Study type
Interventional
Purpose
Treatment
Participants needed
18 (estimated)
Sponsor
Eisai Co., Ltd. · Industry
Who this trial is looking for

This trial is looking for people with mild to moderate liver problems to study how a single dose of tasurgratinib affects them. Healthy participants will also be included for comparison.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have a body mass index (BMI) between 18 and 40.
  • I have stable mild or moderate liver impairment.
  • I am a healthy participant matched by age, weight, race, and gender.

You may not be able to join if

  • I have a serious eye condition.
  • I am HIV positive.
  • I have a prolonged QT interval on my ECG.
  • I have had a serious illness in the past 8 weeks.
  • I have severe swelling or confusion related to my liver problems.
  • My liver medication has not been stable for at least two weeks.
  • I have syphilis.
  • I have abnormal test results needing treatment based on a doctor’s opinion.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

The primary purpose of the study is to evaluate the effects of mild and moderate hepatic impairment on PK of tasurgratinib after a single dose administration.

Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Body mass index (BMI) between 18 to 40 kilogram per square meter (kg/m\^2). 2. For Cohorts A and B: stable hepatic impairment conforming to Child-Pugh classification A and B. 3. For Cohort C: healthy participants matched to participants with hepatic impairment with regard to …
Contacts

Inquiry Service.

eisai-chiken_hotline@hhc.eisai.co.jp

CONTACT