Shortened Antibiotic Treatment of 5 Days in Gram-negative Bacteremia
Recruiting
Phase 4
Interventional Study
Gram-negative Bacteremia
Urinary Tract Infection Bacterial
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 380 (estimated)
- Sponsor
- Thomas Benfield · Other
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About This Trial
GNB5 is an investigator-initiated multicentre non-inferiority randomized controlled trial which aims to assess the efficacy and safety of shortened antibiotic for patients hospitalized with a Gram negative bacteremia with a urinary tract source of infection (GNB).
Five days after initiation of antimicrobial therapy for GNB, participants are randomized 1:1 to parallel treatment arms: 5 days (inter…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age \>18 years
* Blood culture positive for Gram-negative bacteria
* Evidence of urinary tract source of infection (positive urine culture or at least one clinical symptom compatible with urinary tract infection)
* Antibiotic treatment with antimicrobial activity to Gram-negat…
Contacts