Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
Recruiting
Phase 1
Phase 2
Interventional Study
Obesity
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 45
- Sex
- Any
- Trial phase
- Phase 1/2
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 40 (estimated)
- Sponsor
- University of North Carolina, Chapel Hill · Other
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About This Trial
The goal of this study is to understand the role of brain glucose transport in individuals with obesity and the association with cerebral hypometabolism and these individuals' response to plasma glucose elevations. The main premise is that obesity leads to reduced brain glucose transport and that we can measure this reduction with magnetic resonance spectroscopy (MRS). The secondary premises are t…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age 18-45 years
* HbA1C \<6.5%
* Normal weight individuals: BMI 17-25 kg/m\^2
* Obese individuals: BMI \>30 kg/m\^2
Exclusion Criteria:
* Creatinine \>1.5mg/dL
* Hematocrit \<35% for females and \<39% for males
* ALT and AST \>2.5X upper limit of normal
* Abnormal TSH
* Abno…
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