No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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At a Glance
Age
75 and older
Sex
Any
Study type
Observational
Participants needed
180 (estimated)
Sponsor
University Hospital, Ghent · Other
Who this trial is looking for
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In this pilot study, we will investigate whether - with the current dosing regimens, used in the Ghent University Hospital - pharmacodynamic targets regarding beta-lactam antibiotics (more specific Amoxicilline-Clavulanate, Piperacillin-Tazobactam and Temocillin) are attained in frail patients admitted to the geriatric department.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients presenting at the emergency department and later on admitted to the geriatric department
* Patient age 75 years or older
* Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.
* Patient receiving antibiotic treatment (amoxicillin-c…
Inclusion Criteria:
* Patients presenting at the emergency department and later on admitted to the geriatric department
* Patient age 75 years or older
* Patients with geriatric profile according to KATZ scale, G8 screening test or CIRS score.
* Patient receiving antibiotic treatment (amoxicillin-clavulanate, piperacillin-tazobactam)
* Intravenous access available for blood sampling. For measurement of the peak concentration an intravenous access other than the drug infusion line is required.
Exclusion Criteria:
* Admission to other units than the geriatric department incl. the ICU.
* Absence of informed consent
* Known hypersensitivity to beta-lactam antibiotics
* Patients who received oral amoxicillin-clavulanate prior to admission will not be included in the iv. amoxicillin-clavulanate group.
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