Fever Control Using External Cooling in Mechanically Ventilated Patients With Septic Shock
Recruiting
N/A
Interventional Study
Septic Shock
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 820 (estimated)
- Sponsor
- Centre Hospitalier Intercommunal Creteil · Other
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About This Trial
The best strategy for managing fever in patients with septic shock remains unknown. In a pilot study, the investigators showed that fever control at normothermia allowed a better control of shock and evolution of organ failures. In this second trial the investigators will conduct a multicentre, open-label, randomized controlled, superiority trial in which two strategies will be compared:
1. Respe…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Documented or suspected infection either communautary or hospital acquired
* Septic shock defined by the need for vasopressor and lactate\>2 mmol/l despite adequate fluid resuscitation (sepsis-3 definition)
* Patients under invasive mechanical ventilation
* Body core temperatu…
Contacts