Ofloxacin Concentration-toxicity Relationship in the Elderly
Recruiting
N/A
Interventional Study
Ofloxacin
Bone and Joint Infection
Therapeutic Drug Monitoring
Adverse Drug Reactions
At a Glance
- Age
- 65 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 110 (estimated)
- Sponsor
- Centre Hospitalier Universitaire, Amiens · Other
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About This Trial
Ofloxacin is a gold standard antibiotic for the treatment of bone and joint infections due to sensible staphylococcus strains. However, in the elderly, inter-individual variability of the pharmacokinetics may reduce the efficacy or increase toxicity. The occurrence of ofloxacin side effects is likely to be increased in case of higher exposition. However, the serum concentration-toxicity relationsh…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients aged over 65 years hospitalized at the University Hospital of Amiens for an uncomplicated bone and joint infections
* Indication for oral switch to ofloxacin
Exclusion Criteria:
* Patient refusing to participate in the study
* Patient under guardianship or curators …
Contacts