Vaccination With Autologous Dendritic Cells Loaded With Autologous Tumour Homogenate in Glioblastoma

After signing the informed consent form for pre-screening, patient will assess the procedures to obtain sufficient leukapheretic material for the dendritic cell vaccine manufacturing and will perform the standard radiochemotherapy treatment (Stupp regimen) for the disease. For the pre-screening phase of the study the eligibility criteria are: 1. Histologically confirmed "monofocal" glioblastoma 2. Near-complete resection (= 5 ml residual tumor volume) confirmed by "central neuroradiologist on magnetic resonance imaging (MRI) or CT scan within 72 h postoperative" 3. Karnofsky performance status (KPS) = 70% or performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG) Performance Scale (Appendix A) 4. Be willing and able to provide written informed consent/assent for the pre-screening phase of the trial. 5. Be = 18 years of age on day of signing informed consent. 6. Life expectancy of greater than 12 weeks. 7. Patient suitable for the collection of biological material from leukapheresis: serological tests HIV, hepatitis B virus (HBV), HCV, Treponema pallidum negative; normal cardiological parameters (ECG and cardiological examination); evaluation by transfusionist to exclude possible contraindications to leukapheresis. 8. Patient candidate to standard radiochemotherapy (Stupp regimen) 9. Appropriate 12-lead ECG and echocardiogram. After pre-screening, patient will be enrolled based on subsequent Inclusion Criteria: 1. Histologically confirmed "monofocal" glioblastoma 2. THE AUTOLOGOUS SURGICAL SPECIMEN NEEDED FOR VACCINE MANUFACTURING MUST HAVE BEEN COLLECTED AND SENT TO THE SOMATIC CELL THERAPY LAB OF ISTITUTO SCIENTIFICO ROMAGNOLO PER LO STUDIO E LA CURA DEI TUMORI (IRST) ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO (IRCCS) AND MUST FULFIL ALL THE ACCEPTANCE CRITERIA PRESCRIBED BY THE GOOD MANUFACTURING PRACTICES (GMP) PROCEDURES. 3. Availability of sufficient leukapheretic material for the preparation of the vaccine product. 4. No progressive disease near-complete resection (= 5 ml residual tumor volume) confirmed by MRI after standard radiochemotherapy treatment (Stupp regimen) 5. Patients must have recovered (grade 1 or less by CTCAE 5.0) from all the events related to previous treatments. 6. Be willing and able to provide written informed consent/assent for the trial. 7. Be \>= 18 years of age on day of signing informed consent. 8. Have a Karnofsky performance status (KPS) = 70% or a performance status of 0 or 1 on the ECOG Performance Scale. 9. Demonstrate adequate organ and marrow function Exclusion Criteria: 1. Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy \> 10 mg prednisone equivalent or any other form of immunosuppressive therapy within 7 days prior to the first dose of trial treatment. 2. Has active autoimmune disease that has required systemic treatment in the past 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment. 3. Has a known history of active Bacillus Tuberculosis (TB) 4. Previous treatment with a cancer vaccine 5. Other known malignant neoplastic diseases in the patient's medical history with a disease-free interval of less than 5 years, except basal or squamous cell carcinoma of the skin and in situ carcinoma of the cervix uteri treated with radical surgery. 6. Any known history of or is positivity of any serologic marker indicative of infection by Treponema pallidum, hepatitis B virus (HBsAg, HBsAb, HBcAB), hepatitis C virus (HCVAb, HCV RNA quantitative), human immunodeficiency virus (HIV), whether actual or previous. 7. Has received a live vaccine within 30 days of planned start of study therapy.