Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Recruiting
Observational Study
Postoperative Delirium
Postoperative Cognitive Dysfunction
Thoracic Aortic Aneurysm
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Study type
- Observational
- Participants needed
- 100 (estimated)
- Sponsor
- Radboud University Medical Center · Other
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About This Trial
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery.
The aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium.
Patient undergoing thoracic aortic surgery will hav…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Competent patients ≥ 18 years
* Patients who will undergo thoracic aortic surgery and will therefore receive an external lumbar drain as a standard of care procedure.
Exclusion Criteria:
* Patients with meningitis/encephalitis/brain abscess within the last 6 months
* Patient…
Contacts