Oral Antibiotics for Bone and Joint Infections in Kids
BonE and Joint Infections - Simplifying Treatment in Children Trial
Recruiting
Phase 4
Interventional Study
Bone Infection
Septic Arthritis
Bone and Joint Infection
Osteomyelitis
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 1 – 18
- Sex
- Any
- Trial phase
- Phase 4
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 285 (estimated)
- Sponsor
- Murdoch Childrens Research Institute · Other
Who this trial is looking for
This trial is looking for children aged 1 to 18 with bone and joint infections. Participants will receive either all oral antibiotics or standard treatment that starts with an IV and then switches to oral antibiotics.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 1 and 18 years old.
- I have an acute, uncomplicated bone or joint infection.
- My infection was acquired in the community.
You may not be able to join if
- I have an infection due to bacteria resistant to cefalexin.
- I show signs of sepsis, like organ dysfunction.
- I have a severe invasive infection.
- I have a complicated infection.
- I am allergic to cephalosporin antibiotics.
- I've had more than three doses of antibiotics for this infection.
- I have had a prior episode of osteomyelitis or septic arthritis.
- I have a condition that affects absorption or complicated disease.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
This is a multi- centre trial of children with bone and joint infections (BJIs) at eight major paediatric hospitals in Australia and New Zealand. The primary objective is to establish if in children with acute, uncomplicated BJIs, entirely oral antibiotic treatment is not inferior to initial intravenous (IV) treatment for 1 to 7 days followed by an oral antibiotic course in achieving full recovery…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Children aged 1 to 18 years with acute, uncomplicated, community-acquired bone and joint infection who fulfil pre-defined clinical criteria.
Exclusion Criteria:
1. Infection due to bacteria resistant to cefalexin or atypical infection (e.g. mycobacterial, fungal)
2. Features…
Contacts