Enhancement of the Haemostatic Effect of Platelets in the Presence of High Normal Concentrations of Von Willebrand Factor

Inclusion Criteria: * Age ≥ 18 years * Admission to intensive care unit * Patients needing platelet transfusion during or after surgery with or without prior treatment with single or dual antiplatelet agents (ASS, Prasugrel, Clopidogrel, Ticagrelor) * Consent by the patient or a family member in addition to the consent of an independent ICU physician Exclusion Criteria: * Patients receiving Factor VIII concentrate before inclusion of the study (Haemate ®) * Women who are pregnant or breastfeeding * Participation in another study with an investigational drug within the 30 days preceding and during the present study * Overt Disseminated Intravascular Coagulation (DIC) * Heparin-induced Thrombocytopenia (HIT) * Thrombotic Thrombocytopenic Purpura (TTP) or Haemolytic uremic Syndrome (HUS) * Idiopathic thrombocytopenic purpura (ITP) * Sepsis * Patients with known inherited thrombocytopathies * Patients with known von Willebrand disease or Haemophilia A * Patients with known hemato-oncological diseases * Previous enrolment into the current study * Contraindications to the class of drugs under study, e.g. known hypersensitivity or allergy to class of drugs or the investigational product.