Pembrolizumab, Olaparib, Recurrent/Advanced Gastric and Gastro-esophageal Junction(GEJ) Cancer

Recruiting Phase 1 Phase 2 Interventional Study
Gastric Cancer Stage IV
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
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At a Glance
Age
19 and older
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
71 (estimated)
Sponsor
Yonsei University · Other
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About This Trial
Pembrolizumab is a potent humanized immunoglobulin G4 (IgG4) monoclonal antibody (mAb) with high specificity of binding to the programmed cell death 1 (PD 1) receptor, thus inhibiting its interaction with programmed cell death ligand 1 (PD-L1) and programmed cell death ligand 2 (PD-L2). Olaparib is a potent PARP inhibitor (PARP1, 2, and 3) that is being developed as a monotherapy as well as for co…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Provided written informed consent for treatment. 2. Age ≥ 19 years old 3. measurable or evaluable disease based on RECIST 1.1. Lesions 4. Eastern Cooperative Oncology Group (ECOG) performance status 0 or 1 on time of patient's allocation. 5. Adequate organ function as defined…
Contacts

Sun Young Rha, MD. Ph.D

82-2-2228-8053

rha7655@yuhs.ac

CONTACT