Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers
Recruiting
Observational Study
E Cigarette Use
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
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Review the details below, then apply to join this clinical trial.
At a Glance
Age
16 and older
Sex
Any
Study type
Observational
Participants needed
150 (estimated)
Sponsor
Western University, Canada · Other
Who this trial is looking for
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This is a longitudinal study of the long-term health impact of e-cigarette smoking on the lungs. Participants will be followed over a period of 5 years, and impacts of e-cigarette smoking on the lungs will be measured with magnetic resonance imaging (MRI) using hyperpolarized xenon-129 gas, pulmonary function tests, exercise capacity, computed tomography images and questionnaires.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
* Male and female participant age ≥16 years.
* Participant has recently started vaping, \>1 and \<5 years weekly use.
* 70 participants will…
Inclusion Criteria:
* Written informed consent must be directly obtained from legally competent participants before any study-related assessment is performed.
* Male and female participant age ≥16 years.
* Participant has recently started vaping, \>1 and \<5 years weekly use.
* 70 participants will be c-cigarette never users.
* 70 participants will be former or current c-cigarette users.
* 10 asymptomatic age and sex-matched healthy people who have never used e- or c-cigarettes will be controls.
Exclusion Criteria:
* Participants with contraindications for undergoing an MRI such as participants with MRI-sensitive implants, tattoos with MRI-sensitive dye and severe claustrophobia.
* Participant is, in the opinion of the investigator, mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand written material.
* Participant unable to perform spirometry or plethysmography maneuvers.
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