Imaging of Solid Tumors Using FAP-2286
Recruiting
Phase 1
Interventional Study
Solid Tumors, Adult
Metastatic Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 and older
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 191 (estimated)
- Sponsor
- Thomas Hope · Other
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About This Trial
This is a multi-arm prospective trial that evaluates the ability of a novel imaging radiolabeled agents to detect metastatic cancer in participants with solid tumors using a gallium 68 (68Ga-) or copper 64 (64Cu-) FAP-2286 tracer. FAP-2286 is a peptidomimetic molecule that that binds to Fibroblast Activation Protein (FAP). FAP is a transmembrane protein expressed on cancer-associated fibroblasts, …
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Age \>= 18 years.
2. Histopathologically confirmed solid tumors in one of the following cohorts:
a. Cohort 1 (n=11): measurable disease is not required for this cohort.
i. Agnostic to tumor type.
b. Cohort 2 (n=95): Metastatic disease present on conventional imagi…
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