NOX4 Biomarkers in Autosomal Dominant Polycystic Kidney Disease

NOX4 and Related Biomarkers in ADPKD

Recruiting Observational Study
Autosomal Dominant Polycystic Kidney Disease
No Placebo Group Every participant receives an active treatment — no one gets a placebo. No Study Drug Researchers observe your health over time — no experimental treatment is given.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
15 – 40
Sex
Any
Study type
Observational
Participants needed
60 (estimated)
Sponsor
Mayo Clinic · Other
Who this trial is looking for

This trial is looking for people with a specific type of kidney disease to help determine how certain markers can show how severe their condition is. Participants will need to provide consent and meet certain health criteria.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have been diagnosed with autosomal dominant polycystic kidney disease.
  • I am aged 15 to 40 years.
  • My kidney function is estimated to be above 70 mL/min/1.73 m2.
  • I am classified as Class 1 A-E based on imaging.

You may not be able to join if

  • I am classified as Class 2 based on imaging.
  • I have a systemic disease affecting my kidneys.
  • I have diabetes.
  • My predicted urine protein excretion is greater than 1 g/24 hrs.
  • I am using antioxidants like vitamins or Nrf2 activators.
  • I have abnormal urinalysis results.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

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About This Trial

To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * ADPKD (based on Ravine et al. criteria) * Class 1 A-E according to imaging classification * Male and female subjects 15 - 40 years of age * Estimated GFR\> 70 mL/min/1.73 m2 (CKD-EPI) * Ability to provide written, informed consent Exclusion Criteria: * Class 2 according to i…
Contacts

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