No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 82
Sex
Any
Study type
Observational
Participants needed
100 (estimated)
Sponsor
University of Virginia · Other
Who this trial is looking for
This trial is looking for adults with liver or lung cancer and healthy volunteers. Participants will help test a new imaging technique that creates detailed moving images of the lungs and liver while breathing.
Are You a Good Fit for This Trial?
You may be able to join if
I am 21 or older
I have a tumor in my lungs or liver
My tumor is less than 7 cm in size
I will receive radiation therapy as part of my treatment
I will have a planning CT scan for my treatment
I have signed consent and can follow the imaging protocol
I am 18 or older (for healthy volunteers)
You may not be able to join if
I have any condition that prevents me from having an MRI
I have trouble lying flat on my back for long periods
I have serious medical or psychological conditions that may interfere
I am too large to fit in the MRI machine
I have claustrophobia
I am pregnant or breastfeeding
I have an active or chronic infection
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!)
This new way of medical imaging is being developed to help canc…
The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!)
This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:The inclusion criteria for lung and liver cancer patients are:
* Patient is 21 or older
* Patient has primary or metastatic tumor(s) in the lungs or the liver
* Diameter of the tumor(s) is less than 7 cm
* Patient will receive radiation therapy (ordered by the treating Radiation …
Inclusion Criteria:The inclusion criteria for lung and liver cancer patients are:
* Patient is 21 or older
* Patient has primary or metastatic tumor(s) in the lungs or the liver
* Diameter of the tumor(s) is less than 7 cm
* Patient will receive radiation therapy (ordered by the treating Radiation Oncologist) as part of their treatment regimen
* Patient will undergo a planning CT scan with tumor motion assessment (planning 4D-CT ordered by the treating Radiation Oncologist) as part of their treatment regimen
* Patient has signed informed consent and is willing to comply with the 4D-MRI imaging protocol
The inclusion criteria for healthy volunteers are:
* Subject is 18 or older
* Subject has signed informed consent and is willing to comply with the 4D-MRI imaging protocol
Exclusion Criteria:
* Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel, etc.
* Subjects who have difficulty lying flat on their back for extended periods of time
* Patients with any serious/poorly controlled medical or psychological conditions that would complicate protocol compliance
* Too large to adequately fit in the magnet bore or RF coils
* Claustrophobia
* Females who are pregnant or lactating
* Presence of active or chronic infection
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