BREAST ADM Trial for Alloplastic Breast Reconstruction

Inclusion Criteria: * All woman aged 21 years or older but less that 65 undergoing unilateral or bilateral mastectomy with alloplastic breast reconstruction using ADM. * Breast reconstruction must be done by means of a two staged process using tissue expanders and ADM based reconstruction followed by implant tissue expander to implant exchange. Exclusion Criteria: * Patients undergoing autologous reconstruction either at the time of mastectomy or in a delayed fashion. * Patients with a history of previous breast reconstruction procedures. * Patients with prior radiation treatment to the breast or with prior mantle radiation * Any patient with a contraindication to breast reconstruction * Patients undergoing an axillary node dissection with clearance * Patients with an allergy to Polysporin or any of its ingredients. * Patients with contraindications to any of the acellular dermal matrices: • DermACELL: Allergy to Gentamicin, Vancomycin\[12\] * The surgeon performing the breast reconstruction may also deem a patient ineligible if intraoperatively, there is evidence of significant mastectomy flap ischemia prior to the initiation of the breast reconstruction procedure.