No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
2,000 (estimated)
Sponsor
Rigshospitalet, Denmark · Other
Who this trial is looking for
This trial is looking for people who have chest pain and may have heart problems. Participants will undergo special heart imaging tests to help doctors understand their condition better.
Are You a Good Fit for This Trial?
You may be able to join if
I have chest pain and may have heart problems.
I need a non-urgent heart evaluation.
I have had previous heart surgery or treatment.
I am 65 or older with chest pain.
I am 50 or older with chest pain, have typical angina symptoms, and at least one heart risk factor.
You may not be able to join if
I have ongoing chest pain that requires urgent heart treatment.
I was hospitalized for acute coronary syndrome in the last 6 months.
I have severe heart valve disease that might need surgery.
I have severe heart failure.
I have conditions that prevent me from understanding the consent form.
I have known atrial fibrillation.
I have severe kidney problems.
I am allergic to x-ray contrast.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
The purpose of the DYNAMITE trial (Dynamic CT stress myocardial perfusion, CT fractional flow reserve (FFR-CT) and coronary CT angiography for optimized treatment strategy in patients with chest pain syndromes) is to determine the ability of combined anatomical and functional cardiac CT imaging to improve morbidity and mortality in patients with suspected or known ischemic heart disease.
Trial Locations
Loading…
Loading trial locations…
Facility
City
State
Country
Status
Eligibility Criteria
Inclusion Criteria:
* Chest pain in patients with clinically suspected or confirmed ischemic heart disease
* Clinical indication for non-acute coronary evaluation
* Status of coronary revascularization
1. With previous coronary revascularization - all patients
2. Without previous coronary reva…
Inclusion Criteria:
* Chest pain in patients with clinically suspected or confirmed ischemic heart disease
* Clinical indication for non-acute coronary evaluation
* Status of coronary revascularization
1. With previous coronary revascularization - all patients
2. Without previous coronary revascularization
1. Age≥65 years - all patients with chest pain
2. Age\>50 - \<65 years - typical angina pectoris and at least one cardiovascular risk factor and/or previous myocardial infarction
* Typical angina requiring all 3 criteria present: a) constrictive discomfort in the front of the chest or in the neck, jaw, shoulder or arm, b) precipitated by physical exertion c) relieved by rest or nitrates within 5 min.
* Cardiovascular risk factors: hypertension, diabetes, hypercholesterolemia, current smoking, family history of ischemic heart disease, previous stroke, peripheral artery disease
Exclusion Criteria:
* Persistent chest pain and signs of ongoing acute myocardial ischemia requiring acute coronary intervention
* Hospitalization and discharge with the confirmed diagnosis acute coronary syndrome (STEMI or NSTEMI) within the last 6 months
* Severe valvular heart disease as primary diagnosis and/or in potential need of percutaneous or surgical valve treatment
* Known severe heart failure (LVEF less than 35%)
* Language, cultural or mental factors preventing the patient from understanding the informed consent form
* Known atrial fibrillation
* Known renal impairment (estimated Glomerular Filtration Rate below \<30 ml/min)
* Known x-ray contrast allergy
* Known intolerance to adenosine infusion
Picking one helps us show the most relevant trials first.
Your results are loading in the background — you can
change this any time from the results page.
Set your location to continue
Find My Trials uses your location to surface clinical trials near you.
Add your city or zip code to your profile and try again.