SHAPE for Portal Hypertension in Children
SHAPE of Portal Hypertension in Children
Recruiting
Phase 2
Interventional Study
Hypertension, Portal
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 6 – 21
- Sex
- Any
- Trial phase
- Phase 2
- Study type
- Interventional
- Purpose
- Diagnostic
- Participants needed
- 120 (estimated)
- Sponsor
- Thomas Jefferson University · Other
Who this trial is looking for
This trial is looking for children with chronic liver disease to test a new ultrasound method for diagnosing portal hypertension. Participants will not have to undergo invasive procedures.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with chronic liver disease without portal hypertension
- I have been diagnosed with chronic liver disease with portal hypertension
You may not be able to join if
- I am pregnant
- I have a known allergy to egg products
- I have had an allergic reaction to Lumason or Sonazoid
- I have biliary atresia with asplenia or polysplenia
- I have had a liver transplant
- I have cystic fibrosis
- I have chronic lung disease
- I have significant heart disease
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
Early diagnosis of portal hypertension is difficult as symptoms rarely manifest until the later stages of liver disease. Both cirrhotic and non-cirrhotic portal hypertension can result in life-threatening complications, the most frequent of which is bleeding from esophageal varices. In children, variceal bleeds are associated with mortality rates of 1-3 %, while life-threatening complications have…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Patients with a diagnosis of chronic liver disease without portal hypertension.
* Patients with a diagnosis of chronic liver disease with portal hypertension.
Exclusion Criteria:
* Subjects who are pregnant.
* Patients with known or suspected hypersensitivity to egg phosphat…
Contacts