Study of the Genetic Factors Involved in Autism and Related Disorders

Inclusion Criteria--------------------------------------------------------------------------------------------------- Probands with Autism Spectrum Disorder * Meet the diagnostic criteria for ASD of the DSM-5 \[American Psychiatric Association, 2013\] based on a consensus between the clinical expertise of expert clinicians, the scores of the Autism Diagnostic Interview-Revised (ADI-R) (Rutter et al, 2003) and those of the Autism Diagnosis Observation Schedule (ADOS-2) (Lord et al, 2012) * Be at least 24 months (no upper age limit) * Somatic and Intellectual state compatible with a blood test * Affiliation to the social insurance * Signature of informed consent by the applicant or by holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship Controls without ASD * At least 24 months old * Somatic and Intellectual state compatible with a blood test * Affiliation to the social insurance * Signature of informed consent by the subject or by holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship Relatives of the probands with ASD or of controls without ASD * At least 24 months old * Somatic and Intellectual state compatible with a blood test * Affiliation to the social insurance * Signature of informed consent by the subject or by holders of parental authority if the subject is a minor or by the guardian if the subject is under guardianship Exclusion Criteria -------------------------------------------------------------------------------------------------- Probands with Autism Spectrum Disorder * Severe Intelectual Deficiency (IQ,35 or developmental age \<18 months) ●. Personal psychiatric history (schizophrenia, bipolar disorder, substance use disorder (except tobacco), recurrent depression disorder, severe instable anxiety disorder) * Personal neurologic history (epilepsy, or severe neurological disease) Relatives of the probands with ASD, of the controls or the controls: ● Medical condition (psychiatric or somatic) not compatible with the inclusion