Adjuvant Chemotherapy for Advanced Cervical Cancer
Clinical Efficacy of Adjuvant Chemotherapy in Patients With Locally Advanced Cervical Cancer Who Did Not Meet the NCCN Guidelines for Adjuvant Treatment After NACT Combined With Surgery
Recruiting
Phase 3
Interventional Study
Uterine Cervical Neoplasms
Cervical Cancer
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Pivotal Trial
This treatment is in the last trial phase before FDA approval.
Prior Safety Data
This treatment has already been tested in at least one earlier human trial.
At a Glance
- Age
- 18 – 70
- Sex
- Female
- Trial phase
- Phase 3
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 340 (estimated)
- Sponsor
- Huazhong University of Science and Technology · Other
Who this trial is looking for
This trial is looking for women diagnosed with cervical cancer that has a large tumor. Participants will receive adjuvant chemotherapy or just have follow-up visits after surgery, depending on certain criteria.
Are You a Good Fit for This Trial?
You may be able to join if
- I have been diagnosed with cervical cancer stage IB3-IIB.
- My tumor is larger than 4 cm.
- I am between 18 and 70 years old.
- I am in good physical condition (ECOG status score ≤1).
- I have enough blood cell counts and liver function.
- I can follow the study requirements and stay in contact.
- I can sign informed consent for the study.
You may not be able to join if
- I did not have the required surgery after neoadjuvant chemotherapy.
- My neoadjuvant and adjuvant chemotherapy regimens are different.
- I have high-risk factors after surgery like lymph node metastasis.
- I have participated in another clinical trial recently.
- I have severe diseases of other important organs.
- I am unable or unwilling to sign informed consent.
- I have a history of drug or alcohol abuse.
- The researchers determined I am not eligible for the study.
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
This is a prospective, phase 3 randomized controlled clinical trial. Cervical cancer patients with FIGO stage IB3, Ⅱ A2 or IIB with tumor size\> 4 cm will be enrolled. Patients will undergo 2-3 cycles of neoadjuvant chemotherapyradical (NACT) followed by laparotomic or laparoscopic hysterectomy + pelvic lymphadenectomy with cervical cancer foci sealed before dissection of the vagina and without ut…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. Clinical stage IB3-IIB cervical cancer (FIGO, 2018 standard) with the tumor diameter \> 4cm before treatment.
2. Pathologically confirmed cervical cancer, including cervical squamous cell carcinoma, adenocarcinoma and adenosquamous carcinoma.
3. Age：18-70 years old.
4. ECOG s…
Contacts