Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility

Inclusion Criteria: * Age ≥ 18 years old * Patient admitted for a septic shock (according to the SEPSIS3 definition: sepsis with persisting hypotension (MAP\<65mmHg or SAP \<90mmHg) requiring vasopressors to maintain MAP\>65mmHg and having a serum lactate level \>2 mmol/L * Patient who received at least 30ml/kg of fluid and absence of fluid responsiveness * Left ventricular ejection fraction \>65% (visual or Simpson method using echocardiography) * Tachycardia \>100 bpm in sinus rhythm with a MAP 65mmHg for more than 1 hour * Patient receiving invasive mechanical ventilation * Patients adapted to the ventilator under sedation and analgesia * Written informed consent * Patient covered by French national health insurance Exclusion Criteria: * Patients with inclusion criteria already present for more than 36 hours * Patient treated with Dobutamine, adrenaline or isoprenaline * Patient currently treated with beta blockers (previous home betablocker treatment is not an exclusion criteria) * Supra ventricular (atrial fibrillation or flutter) or ventricular arrhythmias * Patients with any form of cardiac pacing * Sick sinus syndrome * Severe atrioventricular (AV) nodal conductance disorders (without pacemaker): 2nd or 3rd degree AV block * Known pulmonary hypertension * ScVO2 \<70% * Moribund * Cardiac arrest * Non-treated phaeochromocytoma * Acute asthmatic attack * Pregnant or breastfeeding woman * Patient deprived of liberty by administrative or judicial decision or placed under judicial protection (guardianship or supervision), * Age \<18 years * Hypersensitivity to the active substance or to any of the excipients * Severe bradycardia (less than 50 beats per minute) * Cardiogenic shock * Severe hypotension * Decompensated heart failure when considered not related to the arrhythmia * Severe, uncorrectable metabolic acidosis * Presence of significant bleeding, or * Acute respiratory distress defined by increased oxygen dependency, polypnea \> 30 /min, signs of struggle (pulling, thoraco-abdominal sway) if the patient is not intubated and ventilated.