Metal Levels in Patients with Pulmonary Hypertension
Study Roles of Heavy Metals and Essential Metal Dyshomeostasis in Pulmonary Arterial Hypertension Patients
Recruiting
Observational Study
Pulmonary HypertensionMetal Poison
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 and older
Sex
Any
Study type
Observational
Participants needed
110 (estimated)
Sponsor
Jiapeng Huang · Other
Who this trial is looking for
This trial is looking for patients with pulmonary hypertension and healthy volunteers matched by age and gender. Participants will provide blood and urine samples every six months to study metal levels in their bodies over a year.
Are You a Good Fit for This Trial?
You may be able to join if
I have been diagnosed with pulmonary hypertension
I agree to the study protocol
I am a healthy volunteer
I am matched by age and gender to the patients
You may not be able to join if
I am younger than 18 years
I refuse to participate
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls. PAH patients are evaluated at least every 6 months by the PAH Clinic and blood/urine samples will be obtained at each office visit. Blood, plasma and urine samples will be used to measure 31 metal leve…
Investigators plan to recruit 50 PAH patients from UofL PAH Clinic, with various degrees of severity (25 intermediate risk patients and 20 high risk patients) and 10 age and gender matched controls. PAH patients are evaluated at least every 6 months by the PAH Clinic and blood/urine samples will be obtained at each office visit. Blood, plasma and urine samples will be used to measure 31 metal levels including heavy metals (cadmium, arsenic, cobalt, lead etc.) and essential metals (calcium, copper, iron, zinc, potassium etc.) by the with ICP-MS via the service of ITEMFC. Interactions among the 31 metals in PAH patients, metal concentration differences between intermediate risk PAH, high risk PAH and control groups, the correlation between metal concentrations and the etiology, severity, duration, treatment, and progression of PAH/RV dysfunction over 12 months will be analyzed by CIEHS Biostatistics and Informatics Facility Core.
Trial Locations
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City
State
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Status
Eligibility Criteria
Inclusion Criteria:
* All patients with the diagnosis of pulmonary hypertension
* Agree to the study protocol
* Healthy volunteers
* Age, gender matched controls
Exclusion Criteria:
* Younger than 18 years
* Refusal to participate
Inclusion Criteria:
* All patients with the diagnosis of pulmonary hypertension
* Agree to the study protocol
* Healthy volunteers
* Age, gender matched controls
Exclusion Criteria:
* Younger than 18 years
* Refusal to participate
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