This will be a single center (OHSU) proof of concept trial to demonstrate that directional deep brain stimulation (DBS) creates a larger therapeutic window for the treatment of essential tremor (ET), effectively treats ET, and minimizes effects on speech, gait and balance compared to nondirectional DBS.
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Eligibility Criteria
Inclusion Criteria:
* A tremor syndrome of bilateral upper limb action tremor with at least 3 years' duration
Exclusion Criteria:
* Patients who have decided not to receive DBS for control of their medication-refractory essential tremor.
* Patients with secondary tremor (ie not Essential Tremor),…
Inclusion Criteria:
* A tremor syndrome of bilateral upper limb action tremor with at least 3 years' duration
Exclusion Criteria:
* Patients who have decided not to receive DBS for control of their medication-refractory essential tremor.
* Patients with secondary tremor (ie not Essential Tremor), such as side effects from medications, secondary to another identified neurologic disease (eg multiple sclerosis, -----Parkinson's disease, dystonia).
* Prior history of deep brain stimulation.
* Prior history of thalamotomy.
* A history or signs of dystonia, ataxia or parkinsonism.
* Task specific tremor.
* Orthostatic tremor.
* Patients with cardiac pacemakers, defibrillators, or neurostimulators.
* Patients who require MRI, ECT, rTMS, or diathermy.
* Subjects with other type of neurological disease or injury.
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