Understanding Nerve Signals in Hypertension and Obesity
Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
Recruiting
Early Phase 1
Interventional Study
Hypertension
Obesity
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
At a Glance
- Age
- 18 – 55
- Sex
- Any
- Trial phase
- Early Phase 1
- Study type
- Interventional
- Purpose
- Basic Science
- Participants needed
- 100 (estimated)
- Sponsor
- University of Texas Southwestern Medical Center · Other
Who this trial is looking for
This trial is looking for people between 18 and 55 years old to study how stress affects blood pressure. Participants will help researchers understand the link between the nervous system, obesity, and high blood pressure by undergoing various stress tests in a lab.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 55 years old
- I have a body mass index (BMI) less than 30
- I have been diagnosed with hypertension
- I am obese with a BMI over 30
- I am obese and have been diagnosed with hypertension
You may not be able to join if
- I have significant cardiovascular disease
- I have renal disease
- I have a history of smoking
- I have diabetes
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hyp…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Control - BMI\<30, age 18-55
* Hypertensive - BMI\<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI\>30, age 18-55 Obese-hypertensive- BMI\>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitori…
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