Lugol's Solution for Hyperthyroidism Surgery

Preoperative Lugol's Solution in Graves' Disease and Toxic Nodular Goiter

Recruiting Phase 3 Interventional Study
Hyperthyroidism
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Pivotal Trial This treatment is in the last trial phase before FDA approval. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 – 75
Sex
Any
Trial phase
Phase 3
Study type
Interventional
Purpose
Treatment
Participants needed
182 (estimated)
Sponsor
Jan Calissendorff · Other
Who this trial is looking for

This trial is looking for people with hyperthyroidism who are scheduled for thyroid surgery. Participants will receive Lugol's solution before their surgery to see if it helps reduce complications.

Are You a Good Fit for This Trial?
Rules you out Type 1 diabetesActive cancerSevere psychiatric illnessAmiodarone treatmentPregnancyBreast feedingIodine hypersensitivity

You may be able to join if

  • I have been diagnosed with hyperthyroidism
  • I am scheduled for thyroid surgery due to toxic nodular goiter or Graves' disease
  • I have a free T4 level below 30 pmol/L
  • I can provide signed consent to participate

You may not be able to join if

  • I have unstable coronary artery disease
  • I have had previous thyroid surgery
  • I have congestive heart failure
  • I have renal insufficiency
  • I have hepatic failure
  • I currently have an infection
  • I am taking steroids or anticoagulants
  • I have thyroid associated orbitopathy CAS greater than 2

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial

The purpose of this study is to assess if preoperative treatment with Lugol's solution prior to thyroidectomy can reduce the surgical complications hypoparathyroidism and laryngeal nerve palsy

Trial Locations
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Eligibility Criteria
Inclusion Criteria: * Hyperthyroidism accepted for thyroidectomy due to toxic nodular goiter with free T4 \<30 pmol/L or Graves' disease * Signed informed consent Exclusion Criteria: * Unstable coronary artery disease * Previous thyroid surgery * Congestive heart failure * Renal insufficiency * H…
Contacts

Jan Calissendorff, MD, PhD

+46(0)8 51770000

jan.calissendorff@regionstockholm.se

CONTACT

Fredric Hedberg, MD

+46(0)8 51770000

fredric.hedberg@regionstockholm.se

CONTACT