No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
No Study Drug
Researchers observe your health over time — no experimental treatment is given.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 100
Sex
Any
Study type
Observational
Participants needed
150 (estimated)
Sponsor
Case Comprehensive Cancer Center · Other
Who this trial is looking for
This trial is looking for adults who have a family history of different types of cancer or who have been diagnosed with cancer themselves. Participants will provide a blood sample for genetic testing to help researchers understand the genetic links to cancer.
Are You a Good Fit for This Trial?
You may be able to join if
I have a family history of cancer.
I have been diagnosed with cancer.
I have a family history of 5 or more different cancers.
I can provide a blood sample for testing.
I can receive genetic counseling.
I have at least one affected and one unaffected family member who can take part.
You may not be able to join if
I cannot safely provide a blood sample.
I cannot receive genetic counseling.
My family has a known high-risk cancer gene.
My family is not suitable for genetic evaluation.
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The purpose of this study is to identify novel gene mutations which have contributed to significant personal and family history of cancer. Adults with and without cancer will be accrued to the study. Participants qualify to take part in this research study because someone in their family has been diagnosed with or because they themselves have a cancer diagnosis.
Participants' DNA and other clinic…
The purpose of this study is to identify novel gene mutations which have contributed to significant personal and family history of cancer. Adults with and without cancer will be accrued to the study. Participants qualify to take part in this research study because someone in their family has been diagnosed with or because they themselves have a cancer diagnosis.
Participants' DNA and other clinical information will be obtained from a blood sample in order to study the genetic basis of cancer and related complications. All portions in the DNA that code for proteins (i.e., the exome) will be studied. Participant DNA sample and information about family structure and family medical history and ethnic origin may also be collected to better understand this information. Clinical information will be stored and biological samples, including DNA, will be kept for up to three (3) years after collection for future. Ultimately, once identified, the role of the specific genetics changes in the development of inherited cancer(s) will be characterized.
Trial Locations
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Status
Eligibility Criteria
Inclusion Criteria:
* Affected patient with a family history suggestive of a known hereditary syndrome or meeting NCCN criteria for germline testing and consent to a multicancer panel
--This cohort is meant as a real world control group receiving routine standard of care and is not eligible for …
Inclusion Criteria:
* Affected patient with a family history suggestive of a known hereditary syndrome or meeting NCCN criteria for germline testing and consent to a multicancer panel
--This cohort is meant as a real world control group receiving routine standard of care and is not eligible for WES.
* Affected patient with a family history of 5 or more discordant cancers in unilateral descent within a 3-generation pedigree.
* Unaffected family members within such kindreds will be eligible for WES as long as a minimum of 2 affected and 1 unaffected family members consent to WES as trial participants.
Exclusion Criteria:
* Unable to safely provide a blood sample for genetic testing
* Unable to receive or decline to receive genetic counselling through the telephone, video conference, or in person
* Families known to segregate a previously identified high penetrance cancer susceptibility gene identified through routine medical genetics evaluation are not eligible WES
* Family is not amenable to routine medical genetics SOC genetics evaluation.
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