No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
Healthy Volunteers Welcome
You do not need to have the condition being studied to take part.
Ready to participate?
Review the details below, then apply to join this clinical trial.
At a Glance
Age
18 – 80
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
28 (estimated)
Sponsor
Kessler Foundation · Other
Who this trial is looking for
This trial is looking for people who have had a stroke affecting the left side of the brain and have reading difficulties. Participants will use a special brain imaging technique to help improve their reading skills.
Are You a Good Fit for This Trial?
You may be able to join if
I have had my first stroke in the last 3 months
I am between 18 and 80 years old
I speak and read English fluently
I have reading difficulties
You may not be able to join if
I cannot give my consent or complete the study tasks
I cannot have an MRI due to pregnancy or other reasons
I have a history of brain tumor or Alzheimer's disease
Summarized in plain language from this trial's official eligibility criteria.
The full criteria are further down this page — only the research team can
confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left langua…
The overall goal of this project is to advance a biologically-based approach to treatment of reading disorders after stroke, which will expand the limits of cognitive rehabilitation. Using a novel brain imaging technique, called real-time functional magnetic resonance imaging (fMRI) neurofeedback combined with right hand motor imagery, this project will re-instate brain activity in the left language-dominant hemisphere. Stroke patients will practice modulating their own brain activity using fMRI neurofeedback signal and will select the most effective mental strategies that help them maintain brain activation patterns associated with better reading recovery.
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer
* Age: 18 - 80 years old
* Fluent and literate in English prior to stroke
* Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehen…
Inclusion Criteria:
* First-ever left-hemisphere stroke \< 3 months prior to study recruitment or healthy volunteer
* Age: 18 - 80 years old
* Fluent and literate in English prior to stroke
* Reading deficits, defined as \>3 errors on the Paragraphs test (subtests VIII, IX) of the Reading Comprehension Battery for Aphasia-2nd ed. (RCBA-2) in keeping with the healthy control accuracy criterion of 86-100% correct.
Exclusion Criteria:
* Inability to consent or complete study tasks
* Inability to undergo MRI (e.g., pregnancy, non-MRI compatible implants, claustrophobia)
* A history of prior neurological disease (e.g., brain tumor, Alzheimer's disease)
Contacts
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