BMS-986340 for Advanced Solid Tumors

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

Recruiting Phase 1 Phase 2 Interventional Study
Cervical Cancer Gastric/Gastroesophageal Junction Adenocarcinoma Microsatellite Stable Colorectal Cancer Non-Small-Cell Lung Cancer Squamous Cell Carcinoma of Head and Neck Carcinoma, Renal Cell Urothelial Carcinoma Pancreatic Adenocarcinoma Melanoma Ovarian Neoplasms Triple Negative Breast Neoplasms
No Placebo Group Every participant receives an active treatment — no one gets a placebo. Prior Safety Data This treatment has already been tested in at least one earlier human trial.
Ready to participate?

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At a Glance
Age
18 and older
Sex
Any
Trial phase
Phase 1/2
Study type
Interventional
Purpose
Treatment
Participants needed
1,109 (estimated)
Sponsor
Bristol-Myers Squibb · Industry
Who this trial is looking for

This trial is looking for people with advanced solid tumors to assess the safety and correct dose of a new drug called BMS-986340. Participants will need to provide tumor samples and have measurable disease.

Are You a Good Fit for This Trial?

You may be able to join if

  • I have measurable disease with at least one tumor that can be biopsied.
  • I have had progressive disease after my last treatment.
  • I have a performance status of 0 or 1.
  • I have received standard cancer therapies.
  • I have advanced or metastatic disease.
  • I can provide fresh tumor samples for testing.

You may not be able to join if

  • I am pregnant or breastfeeding.
  • I have a primary brain cancer.
  • I have untreated brain metastases.
  • I have an autoimmune disease.
  • I have had major surgery in the last 4 weeks.
  • I have a history of interstitial lung disease.
  • I have concurrent cancer that requires treatment.
  • I have had a prior organ transplant.

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

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About This Trial

The purpose of this study is to assess the safety, tolerability, and recommended dose(s) of BMS-986340 as monotherapy and in combination with nivolumab, docetaxel, or Pumitamig in participants with advanced solid tumors. This study is a first-in-human (FIH) study of BMS-986340 in participants with advanced solid tumors.

Trial Locations
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Eligibility Criteria
Inclusion Criteria * Fresh pre-treatment and on-treatment tumor biopsy must be provided for biomarker analysis. * Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1 and at least 1 lesion accessible for biopsy. Fine needle biopsy, cytology, and bone lesion biopsies are…
Contacts

BMS Clinical Trials Contact Center www.BMSClinicalTrials.com

855-907-3286

Clinical.Trials@bms.com

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First line of the email MUST contain NCT # and Site #.

CONTACT