FGF19 and Chronic Kidney Disease

Inclusion Criteria: -For the patient population: * estimated GFR \<60 ml / min / 1.73m2 according to the CKD-EPI formula OR patients dialyzed for more than 3 months * No history of kidney transplant * BMI between 18 and 30 kg / m² * For women of childbearing age, at least one method of contraception recognized as effective * Willing and able to give informed consent For control group: * Potential living kidney donor * Willing and able to give informed consent For all of the study participants: o Non diabetic (fasting blood glucose \<1.26 g / L, or absence of insulin or oral antidiabetic treatment) Exclusion Criteria: * For the patient population: * Subjects with a history of colectomy, gut resection or cholecystectomy * Having received antibiotics, prebiotics, probiotics in the last 3 months. * Taking a high dose laxative treatment (\> 2 doses per day) in the last 3 months * Hemoglobin \<7 g / dl or \<9 g / L in case of previous cardiovascular disease * For control group: * DFGe ≤ 80 ml / min / 1.73m2 according to CKD-EPI * High blood pressure (PA≥140 / 90 mmHg) or taking antihypertensive treatment * Presence of proteinuria (\> 0.15 g / 24h) or micro-albuminuria (\> 3 mg / mg creatinuria) or hematuria (\> 20 GR / mm3) * For all of the study participants: * Hemoglobin \<7 g / dl or \<9 g / L in case of previous cardiovascular disease * Active inflammatory, infectious, cardiovascular or neoplastic disease * Period of exclusion from a previous study or already participating in a clinical research protocol having an impact on the study judgment criteria * Exposure to ionizing radiation (medical radiological examinations or occupational exposure with exposure greater than 20 mSv) in the 6 months preceding inclusion * No affiliation to social security * Patient under guardianship or safeguarding justice * Pregnant patient (a pregnancy test will be carried out for women of reproductive age o For the patients and control group will accept muscles biopsies * Presence of a precarious venous capital that does not allow the placement of a venous catheter - Thrombocytopenia * History of arrhythmias or cardiac conduction disorders * Taking anticoagulant and / or antiplatelet agent * Pulse \<50 bpm * Allergy to local anesthetics and / or plaster