Phenylalanine-free Diet for Patients With Secondary Hyperphenylalaninemia in ICU
Recruiting
N/A
Interventional Study
Non-Phenylketonuric Hyperphenylalaninemia
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 20 and older
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 100 (estimated)
- Sponsor
- Chang Gung Memorial Hospital · Other
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About This Trial
Hyperphenylalaninemia is not only present in patients with congenital phenylketonuria. In adults with critical illness, hyperphenylalaninemia is noted in some patients and is associated with high mortality rate. Hyperphenylalaninemia can cause metabolic acidosis, brain dysfunction, and metabolic disturbance. The investigators would like to see whether the phenylalanine-free milk for congenital phe…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
1. had Acute Physiology And Chronic Health Evaluation (APACHE II) scores of ≥15;
2. were expected to stay in the ICU \>48 hours;
3. patients with baseline PHE levels of ≥95 uM;
4. were over 20 years old.
Exclusion Criteria:
1. patients with comorbid disorders other than the ma…
Contacts