Lung Ventilation Support for Moderate ARDS
Ultra-Protective Lung Ventilation With Extracorporeal CO2 Removal for Moderate ARDS
Recruiting
N/A
Interventional Study
Acute Respiratory Distress Syndrome
No Placebo Group
Every participant receives an active treatment — no one gets a placebo.
At a Glance
- Age
- 18 – 100
- Sex
- Any
- Study type
- Interventional
- Purpose
- Treatment
- Participants needed
- 230 (estimated)
- Sponsor
- University of Bologna · Other
Who this trial is looking for
This trial is looking for adults with moderate Acute Respiratory Distress Syndrome (ARDS) who are on mechanical ventilation. If eligible, you may receive a special type of lung support treatment to see if it helps you breathe better.
Are You a Good Fit for This Trial?
You may be able to join if
- I am 18 years or older
- I have been on mechanical ventilation for 4 days or less
- I have a specific level of oxygen in my blood after ventilation
- I have low compliance of my respiratory system
- I have a high ventilatory ratio
- I have lung opacities
- I have respiratory failure not due to heart issues
- I have not improved with standard ventilation settings
You may not be able to join if
- I am pregnant
- I have very severe ARDS
- I am expected to need mechanical ventilation for less than 2 days
- I have severe COPD
- I have chronic respiratory issues requiring home oxygen
- I currently receive ECMO therapy
- I have a severe brain injury
- I have had burns covering more than 40% of my body
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer a few quick questions to see if you may meet the eligibility requirements.
Check Your Eligibility
About This Trial
Acute respiratory distress syndrome (ARDS) accounts for 10% of all ICU admissions and for 23% of patients requiring mechanical ventilation (MV). Its hospital mortality remains high, ranging from 34% in mild forms up to 46% in severe cases. Positive pressure MV remains the cornerstone of management, but at the same time it can contribute to worsening and maintenance of the lung injury when excessiv…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Age ≥ 18 years
* On invasive mechanical ventilation for ≤ 96 hours
* Presence of all of the following conditions for ≤ 24 hours: 100 \< PaO2/FiO2 ≤ 200 after 12 hours of "standardized ventilation" with PEEP ≥ 5; compliance of the respiratory system ≤ 0.5 ml/cmH2O per kg PBW; v…
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