Fecal Microbiota Transplant for Ulcerative Colitis Flare

Screening Donors, Fecal Microbiota Transplant Program in Ulcerative Colitis

Recruiting N/A Interventional Study
Ulcerative Colitis Flare
No Placebo Group Every participant receives an active treatment — no one gets a placebo.
Ready to participate?

Review the details below, then apply to join this clinical trial.

At a Glance
Age
18 and older
Sex
Any
Study type
Interventional
Purpose
Treatment
Participants needed
200 (estimated)
Sponsor
Hamilton Health Sciences Corporation · Other
Who this trial is looking for

This trial is looking for adult patients with active ulcerative colitis. Participants will receive a fecal microbiota transplant to see if it can help improve their condition.

Are You a Good Fit for This Trial?

You may be able to join if

  • I am 18 years old or older
  • I have active ulcerative colitis
  • I have a Mayo score greater than 3
  • I have a Mayo endoscopic score greater than 0
  • I can use acceptable contraception if I am a woman of child-bearing potential

You may not be able to join if

  • I am participating in another study for ulcerative colitis
  • I cannot give informed consent
  • I have a severe medical illness
  • I have severe ulcerative colitis that requires hospitalization
  • I have increased my ulcerative colitis therapy in the last 12 weeks
  • I have taken antibiotics in the last 30 days
  • I am pregnant
  • I have significant liver or kidney dysfunction

Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.

Think this trial could be right for you?

Answer a few quick questions to see if you may meet the eligibility requirements.

Check Your Eligibility
About This Trial
The investigators intend to screen for new donors, given that there may a donor effect (PubMed ID: 25857665), with some donors not inducing remission in any patient whilst others inducing remission in 20-40% of cases. It is important to give UC patients participating in RCTs stool that has been demonstrated to be effective in some patients. We therefore propose to conduct an open label study in pa…
Trial Locations
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Eligibility Criteria
Inclusion Criteria: 1. Patients aged 18 or over 2. Active UC defined as a Mayo score (7) \>3 3. A Mayo endoscopic score (7) \>0 4. Females of child-bearing potential must be willing and able to use acceptable contraception as per Appendix III. II. b. Toxicity section of the Health Canada Guidance …
Contacts

Melanie A Wolfe, CCRP

9055212100

wolfe@hhsc.ca

CONTACT

Aida Fernandes, MBA

289-921-6483

fernaa19@mcmaster.ca

CONTACT