Clonidine for Obesity-Related Inflammation
Mitigating the Pro-inflammatory Phenotype of Obesity
Recruiting
Phase 1
Interventional Study
Blood Pressure
Diabetes
Obesity
Insulin Resistance
Diuretics Drug Reactions
Sympathetic Nerve Activity
At a Glance
- Age
- 18 – 79
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 60 (estimated)
- Sponsor
- University of Kansas Medical Center · Other
Who this trial is looking for
This trial is looking for people who are obese and have high blood pressure or insulin resistance. Participants will take a medication called clonidine for four weeks and will need to visit a research lab for blood tests.
Are You a Good Fit for This Trial?
You may be able to join if
- I am between 18 and 79 years old
- I am obese with a BMI over 30
- I have high blood pressure over 130/80
- I have elevated insulin resistance
- I have a waist size over 102 cm (men) or 88 cm (women)
- My fasting glucose is under 126 mg/dL
- My fasting triglycerides are under 250 mg/dL
- I can provide written informed consent
You may not be able to join if
- I currently use clonidine or beta-blockers
- I smoke or smoked in the last 3 months
- I have high fasting triglycerides over 250 mg/dL
- I am currently taking medication for high blood pressure
- I have a history of heart disease
- I have a history of neurological disorders
- I have had a transplant
- I am participating in other studies
Summarized in plain language from this trial's official eligibility criteria. The full criteria are further down this page — only the research team can confirm whether you qualify.
Think this trial could be right for you?
Answer three quick questions written from this study's own rules to see if you may qualify. No account needed to find out.
Check Your Eligibility
About This Trial
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6).
Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral cloni…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Male or Female, age 18-79
* Obese: BMI \> 30 m/kg2
* Hypertensive: blood pressure \>130/80
* Elevated insulin resistance (HOMA-IR \> 2.5)
* Waist circ: \>102 cm (men) and \>88 cm (women)
* Fasting glucose \< 126 mg/dL
* Fasting triglycerides \< 250 mg/dL
* HbA1c \< 6.5%
* Will…
Contacts