Mitigating the Pro-inflammatory Phenotype of Obesity
Recruiting
Phase 1
Interventional Study
Blood Pressure
Diabetes
Obesity
Insulin Resistance
Diuretics Drug Reactions
Sympathetic Nerve Activity
At a Glance
- Age
- 18 – 79
- Sex
- Any
- Trial phase
- Phase 1
- Study type
- Interventional
- Purpose
- Other
- Participants needed
- 60 (estimated)
- Sponsor
- University of Kansas Medical Center · Other
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About This Trial
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell expression of inflammatory markers (e.g., TNF-α, IL-6).
Our study is a prospective study using a randomized, double-blinded design to test 4 weeks of SNA blockade (oral cloni…
Trial Locations
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Eligibility Criteria
Inclusion Criteria:
* Male or Female, age 18-79
* Obese: BMI \> 30 m/kg2
* Hypertensive: blood pressure \>130/80
* Elevated insulin resistance (HOMA-IR \> 2.5)
* Waist circ: \>102 cm (men) and \>88 cm (women)
* Fasting glucose \< 126 mg/dL
* Fasting triglycerides \< 250 mg/dL
* HbA1c \< 6.5%
* Will…
Contacts